Endocrine Abstracts

Objectives: Graves’ disease (GD) is a common cause of hyperthyroidism. An increased heart rate (HR) is a hallmark of elevated thyroid hormones (TH). In a prospective observational study we monitored HR continuously with wearable fitness trackers to evaluate the correlation between HR and TH levels and the relevance of HR monitoring for clinical management of patients with GD.Methods: Seventeen outpatients with newly diagnosed or relapsed GD starting...

Background: Thyroid hormones have been shown to be necessary for proper function of brown adipose tissue (BAT) and cold induced thermogenesis (CIT) in rodent models. In humans hyperthyroidism has been demonstrated to activate BAT and increase thermogenesis. However, the data on CIT in humans in the hypothyroid vs. the euthyroid state are limited and conflicting.Methods: This was a prospective observational study. We recruited 40 patients presenting to a ...

Background: Humans and other mammals need to maintain a stable core body temperature. Energy expenditure increases in response to a mild cold stimulus, this is called cold induced thermogenesis (CIT). Recently, thermogenic brown adipose tissue (BAT) has been found to play an important role for CIT in human adults. It is known that energy expenditure and CIT are acutely influenced by ambient temperature. In the present study, we investigated the effect of seasonal temperature v...

Background: Imaging of brown adipose tissue (BAT) is currently performed with combined positron emission tomography and x-ray computed tomography (PET-CT). Recent studies showed promising imaging features of BAT with magnetic resonance imaging (MRI) through modified 2-point-dixon (mDixon) water-fat separation method. The aim of this study was to establish a reliable MRI-procedure for quantification of BAT volumes and weighted fat-fraction (WFF) and to correlate them to cold-in...